Drug Combination Safety Chart
A free, evidence-based chart of how 23 common substances interact, color-coded from dangerous to low risk. Built from our interactive interaction checker, where every pairing links to its mechanism and citations. Free to download, print for events, or embed on your own site.
Embed this chart on your site
Copy the snippet below. It displays the chart and links back to our interactive checker, so your readers can dig into the mechanism and sources behind any pairing. Free to use with attribution.
How to read the chart
- Dangerous: do not combine. Risk of death or serious harm (for example GHB + alcohol, opioids + benzos, MAOIs + MDMA).
- High risk: strongly discouraged. Significant danger such as serotonin syndrome or the redose trap.
- Caution: extra care needed. Lower doses, monitoring, and timing matter.
- Low risk: generally lower risk, but never zero risk.
- No data: we do not have enough evidence to rate it. An empty square does not mean a combination is safe.
Find a square by tracing across its row and up its column to the labeled diagonal. Risk ratings summarize published evidence and harm-reduction consensus. This chart is not medical advice. For the reasoning and citations behind any pairing, use the interactive checker.
License and attribution
You are welcome to share, print, and embed this chart for free, including in harm-reduction materials, slideshows, and event signage. The only ask: keep a visible link back to ravewellness.org/interactions so people can reach the sourced, interactive version. The chart updates as our interaction data does.